Product Name :
EZH2-IN-5
Description:
EZH2-IN-5 is a potent EZH2 inhibitor with IC50 values of 1.52 nM and 4.07 nM for wild-type and mutant Tyr641 EZH2, respectively.
CAS:
1403258-69-4
Molecular Weight:
517.50
Formula:
C26H37BrN4O2
Chemical Name:
5-Bromo-N-[(1, 2-dihydro-4, 6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[[trans-4-(dimethylamino)cyclohexyl]ethylamino]-2-methylbenzamide
Smiles :
CN(C)[C@@H]1CC[C@H](CC1)N(CC)C1=CC(Br)=CC(C(=O)NCC2C(=O)NC(C)=CC=2C)=C1C
InChiKey:
FKKHGOZTTQASQA-MEMLXQNLSA-N
InChi :
InChI=1S/C26H37BrN4O2/c1-7-31(21-10-8-20(9-11-21)30(5)6)24-14-19(27)13-22(18(24)4)25(32)28-15-23-16(2)12-17(3)29-26(23)33/h12-14,20-21H,7-11,15H2,1-6H3,(H,28,32)(H,29,33)/t20-,21-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Alirocumab Description
Additional information:
EZH2-IN-5 is a potent EZH2 inhibitor with IC50 values of 1.Palivizumab NF-κB 52 nM and 4.07 nM for wild-type and mutant Tyr641 EZH2, respectively.|Product information|CAS Number: 1403258-69-4|Molecular Weight: 517.50|Formula: C26H37BrN4O2|Chemical Name: 5-Bromo-N-[(1, 2-dihydro-4, 6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[[trans-4-(dimethylamino)cyclohexyl]ethylamino]-2-methylbenzamide|Smiles: CN(C)[C@@H]1CC[C@H](CC1)N(CC)C1=CC(Br)=CC(C(=O)NCC2C(=O)NC(C)=CC=2C)=C1C|InChiKey: FKKHGOZTTQASQA-MEMLXQNLSA-N|InChi: InChI=1S/C26H37BrN4O2/c1-7-31(21-10-8-20(9-11-21)30(5)6)24-14-19(27)13-22(18(24)4)25(32)28-15-23-16(2)12-17(3)29-26(23)33/h12-14,20-21H,7-11,15H2,1-6H3,(H,28,32)(H,29,33)/t20-,21-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33232052 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|EZH2-IN-5 (compound 276) inhibits cell growth of WSUDLCL2 cell lines with an IC50 of 187.28 nM.|Products are for research use only. Not for human use.|