Dystrophin serves as a critical structural link between the dystrophin-glycoprotein complex (DGC) and the actin cytoskeleton. Our previous work has demonstrated that DGC subunits function as markers for airway smooth…
Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants that have become pervasive environmental contaminants. Among these, PBDE-47 is one of the most commonly detected congeners in human tissues. Once…
KRAS-mutant non-small cell lung cancer (NSCLC) represents a significant subset of lung adenocarcinoma, accounting for approximately 20–40% of cases, with higher prevalence among smokers and Western populations. Despite being the…
Platelets play a pivotal role beyond hemostasis, contributing significantly to inflammation, angiogenesis, and tissue repair. During percutaneous coronary intervention (PCI), endothelial injury and contact with foreign surfaces trigger platelet activation…
DNA methylation is a fundamental epigenetic mechanism that regulates gene expression and maintains genome stability across eukaryotes. In *Arabidopsis thaliana*, cytosine methylation occurs in three sequence contexts: CG, CHG, and…
The regulation of Mcl-1 stability is a critical determinant of cancer cell survival and resistance to chemotherapy. This study demonstrates that inhibition of protein phosphatase 2A (PP2A) leads to sustained…
Malaria remains a significant public health challenge in tropical regions, particularly in endemic areas such as Jharkhand, India. This study aimed to investigate the influence of Plasmodium falciparum and Plasmodium…
**Background** Dihydrofolate reductase (DHFR) is a critical enzyme in the folate pathway, responsible for reducing dihydrofolate to tetrahydrofolate, which serves as a vital precursor for the synthesis of DNA and…
Hepatocellular carcinoma (HCC) remains a major global health challenge, ranking as the fifth most common cancer and third leading cause of cancer-related mortality. Despite advances in surgical resection, liver transplantation,…
DNA methylation is a fundamental epigenetic mechanism that plays a crucial role in regulating gene expression without altering the underlying DNA sequence. This process involves the addition of a methyl…