.3) 1.25 (0.99sirtuininhibitor.57) General mortality 1.01 (0.81sirtuininhibitor.26) 1.01 (0.79sirtuininhibitor.three) 0.78 (0.31sirtuininhibitor.98) 0.9 (0.81sirtuininhibitor) 0.91 (0.8sirtuininhibitor.03) 0.88 (0.77sirtuininhibitor) 0.94 (0.84sirtuininhibitor.05) 0.92 (0.83sirtuininhibitor.
.three) 1.25 (0.99sirtuininhibitor.57) All round mortality 1.01 (0.81sirtuininhibitor.26) 1.01 (0.79sirtuininhibitor.3) 0.78 (0.31sirtuininhibitor.98) 0.9 (0.81sirtuininhibitor) 0.91 (0.8sirtuininhibitor.03) 0.88 (0.77sirtuininhibitor) 0.94 (0.84sirtuininhibitor.05) 0.92 (0.83sirtuininhibitor.01) 0.87 (0.79sirtuininhibitor.96) 0.97 (0.88sirtuininhibitor.07) 1.19 (0.96sirtuininhibitor.48) 0.97 (0.85sirtuininhibitor.11) 0.94 (0.85sirtuininhibitor.04) Main bleeding 1.09 (0.82sirtuininhibitor.45) 1.29 (0.76sirtuininhibitor.15) 0.39 (0.08sirtuininhibitor.02) 0.69 (0.6sirtuininhibitor.8) 0.8 (0.7sirtuininhibitor.93) 0.93 (0.93sirtuininhibitor.07) 1.03 (0.9sirtuininhibitor.19) 0.80 (0.71sirtuininhibitor.91) 0.47 (0.41sirtuininhibitor.55) 1.53 (1.26sirtuininhibitor.87) 0.75 (0.42sirtuininhibitor.31) 1.16 (1sirtuininhibitor.34) 0.60 (0.51sirtuininhibitor.7) Intracranial hemorrhage 1.92 (0.92sirtuininhibitor.98) 0.54 (0.2sirtuininhibitor.38) 0.33 (0.01sirtuininhibitor.01) 0.42 (0.3sirtuininhibitor.57) 0.three (0.19sirtuininhibitor.45) 0.41 (0.28sirtuininhibitor.6) 0.67 (0.Carbonic Anhydrase 2 Protein custom synthesis 47sirtuininhibitor.93) 0.47 (0.34sirtuininhibitor.63) 0.3 (0.21sirtuininhibitor.43) 1.84 (1.17sirtuininhibitor.9) 0.46 (0.14sirtuininhibitor.31) 1.39 (0.85sirtuininhibitor.28) 0.66 (0.44sirtuininhibitor.98)Notes: A correction of 0.5 was added to every single count, due to zero events in the placebo arm. Outcomes presented as rate ratios, with 95 self-confidence intervals in parentheses beneath. Important results are in bold. Abbreviations: ASA, acetylsalicylic acid (aspirin); C, clopidogrel; HD, high dose; LD, low dose; NA, not applicable.Table five Outcomes of base-case mixed-treatment comparison analysisReference Warfarin Comparator ASA + C Aspirin Placebo Apixaban Dabigatran 110 Dabigatran 150 Rivaroxaban Edoxaban HD Edoxaban LD ASA + C Aspirin Placebo All strokes 1.44 (1.15sirtuininhibitor.8) 1.93 (1.55sirtuininhibitor.41) two.39 (1.77sirtuininhibitor.24) 0.82 (0.69sirtuininhibitor.97) 0.92 (0.75sirtuininhibitor.14) 0.65 (0.52sirtuininhibitor.82) 0.85 (0.7sirtuininhibitor.03) 0.89 (0.76sirtuininhibitor.04) 1.12 (0.96sirtuininhibitor.3) 1.34 (1.17sirtuininhibitor.55) 1.66 (1.29sirtuininhibitor.15) Ischemic stroke 1.87 (1.45sirtuininhibitor.42) 2.68 (two.08sirtuininhibitor.47) three.75 (2.64sirtuininhibitor.33) 0.97 (0.79sirtuininhibitor.19) 1.14 (0.9sirtuininhibitor.44) 0.76 (0.59sirtuininhibitor.99) 0.95 (0.76sirtuininhibitor.18) 1.01 (0.84sirtuininhibitor.21) 1.four (1.IL-27 Protein Biological Activity 18sirtuininhibitor.65) 1.44 (1.23sirtuininhibitor.68) 2.01 (1.5sirtuininhibitor.69) Myocardial infarction 1.05 (0.75sirtuininhibitor.47) 1.22 (0.88sirtuininhibitor.68) 1.96 (0.86sirtuininhibitor.44) 0.87 (0.67sirtuininhibitor.13) 1.23 (0.92sirtuininhibitor.65) 1.2 (0.9sirtuininhibitor.61) 0.82 (0.64sirtuininhibitor.07) 0.94 (0.74sirtuininhibitor.18) 1.17 (0.94sirtuininhibitor.46) 1.16 (0.91sirtuininhibitor.48) 1.87 (0.84sirtuininhibitor.07) General mortality 1.02 (0.88sirtuininhibitor.18) 1.05 (0.91sirtuininhibitor.21) 1.22 (0.94sirtuininhibitor.57) 0.89 (0.8sirtuininhibitor.98) 0.92 (0.81sirtuininhibitor.04) 0.89 (0.79sirtuininhibitor.01) 0.94 (0.84sirtuininhibitor.05) 0.92 (0.84sirtuininhibitor.02) 0.87 (0.78sirtuininhibitor.96) 1.03 (0.94sirtuininhibitor.13) 1.two (0.95sirtuininhibitor.51) Important bleeding 1.16 (0.92sirtuininhibitor.45) 0.77 (0.61sirtuininhibitor.98) 0.57 (0.32sirtuininhibitor) 0.71 (0.62sirtuininhibitor.81) 0.82 (0.71sirtuininhibitor.94) 0.94 (0.82sirtuininhibitor.08) 1.03 (0.9sirtuininhibitor.19) 0.eight (0.71sirtuininhibitor.91) 0.