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In mammals and most vertebrates hemoglobin (Hb) is contained inside of the red blood cell (RBC). Packaging Hb within this method may perhaps reduce the toxicity and tissue damage created by circulating cell-free Hb [1; 2]. Cell-free Hb scavenges endothelium-derived nitric oxide (NO) [3], triggering systemic vasoconstriction [4] and contributing to pathogenic mechanisms which includes thrombosis [5] and inflammation [6]. Solutions of Hb polymers are studied for decades as circulating oxygen carriers to substitute for red blood cells in animal versions and sufferers [7; 8]. Infusing Hb polymers can produce systemic vasoconstriction in humans [4; 9]. On top of that, infu.