Emotion labeling paradigm to test whether or not the neural mechanisms mediating 929016-96-6 Technical Information irritability vary concerning BP and DMDD. Procedures: In the course of fMRI, seventy one youths (24 DMDD, twenty five BD, 22 HV) done an eventrelated experience emotion labeling task with pleased, fearful, and indignant faces of different intensity. In all subjects, trait irritability was characterized dimensionally about the Affective Reactivity Index (ARI). We examined, not merely most important effects of diagnosis (BP, DMDD, HV) and ARI on neural exercise, but in addition prognosis x ARI interactions inside of a wholebrain corrected examination. Benefits: ARI scores didn’t vary among DMDD and BD, and there have been no behavioral differences among teams inAbstractsSthe scanner. We observed a trait x diagnosis conversation during the amygdala, the place irritability correlated with neural activity for all feelings in DMDD, but just for fearful faces in BD. In addition, increased irritability was connected with bigger amygdala action in reaction to delicate fearful faces in BD, but fewer amygdala exercise in DMDD. Other temporal, parietal, and occipital locations showed optimistic correlations involving irritability and Daring reaction to subtle adverse emotion faces in DMDD, but not BD. Conclusions: Whilst irritability severity did not vary involving DMDD and BD, the neural mechanisms mediating irritability did differ considerably between the 2 client teams. These knowledge obstacle the RDoC assumption that, across diagnoses, neural mechanisms mediating a certain trait are automatically a similar. Plainly, this assumption wants being examined for other attributes and throughout other diagnoses. On top of that, the present findings Pub Releases ID:http://results.eurekalert.org/pub_releases/2016-04/e-iwy042616.php add to present longitudinal, familial, and neuroimaging knowledge suggesting that DMDD (characterised by long-term irritability, with no manic episodes) and BP (characterised by episodic mania with or without long-term irritability involving episodes) are unique phenotypes. Disclosures: Nothing at all to reveal.lateral prefrontal cortex. Within these areas, people had been extra prone to exhibit amplified activation in limbic and medial temporal locations and diminished activation while in the thalamus as well as lateral prefrontal cortex. The outcome of RDoC domains was substantial for subcortical locations (amygdala, hippocampus, putamen, nucleus accumbens) but not in cortical regions apart from the medial prefrontal cortex and frontal operculum. Conclusions: These final results present proof in assistance of a frequent purposeful topography across multiple psychiatric issues. A product assuming disorderspecific pathogenesis would have resulted in nominal or no transdiagnostic overlap in useful architecture. As an alternative, the disordergeneral map identified implies that some mind locations are relatively additional susceptible and so prone to be afflicted by a selection of pathogenetic mechanisms. Disclosures: Very little to reveal.Panel 31. Caffeine Interactions with Dopamine in Adolescence: An Unappreciated Hazard for Being overweight and Addiction 31.one Habit Vulnerability Characteristics Following Adolescent Caffeine Use Ryan Bachtell University of Colorado, Boulder, Colorado, United StatesBackground: Caffeine is the most usually used psychoactive material worldwide, and consumption by little ones and adolescents has risen drastically in recent years. Earlier scientific tests have discovered that caffeine consumption in older people is positively correlated with compound use conditions, elevated illicit drug use and increases in stress and anxiety. Now we have lately demonstrated that adolescent caffeine consum.