Curiously, evidence indicates an elevated susceptibility to -syn aggregation in diseases characterized by lysosomal dysfunction, this sort of as Gaucher’s and Niemann-Choose illnesses, underscoring the role of the lysosomes in mediating autophagic clearance of -syn [24,25]
The polysaccharidic capsule is an crucial determinant of enhance resistance, together with lipooligosaccharide, sialic acid, fHbp and NspA uncovered on the area of the pathogen. In certain fHbp and NspA…