We also identified that overexpression of SPARC inhibited tumour cell-induced capillary formation of HUVECs in vitro and angiogenesis in dorsal window assay in vivo
To further characterise the function of VEGF and MMP-seven in SPARC-mediated angiogenesis modulation, MMP-seven-shRNA and 1 mg/ml neutralising VEGF antibody (Chemicon, Temacula, CA, United states) ended up utilised for HGC-sh…