Conversely, knockdown of Klf4 in MM189 cells enhanced cell migration (Determine S3). Very similar outcomes have been noticed following KLF4 knockdown in the human HCC mobile line PLC5 (Figure S3)
Regular with potential tumor suppressor action, the over-expression of KLF4 decreased in vitro and in vivo tumorigenecity of colonic and gastric cancer cells . Recent reports figuring out transcriptional targets…