Product Name :
Rabbit anti-BMI1 Polyclonal Antibody(C-term)
Synonym :
Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; PCGF4; RNF51
Host :
Rabbit
Species Reactivity:
Human, Mouse
Specificity :
This BMI1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 281-314 amino acids from the C-terminal region of human BMI1.
Predicted Reactivity:
Applications :
IF~~1:25WB~~1:1000-1:2000
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
Cancer;Cell Biology;Stem Cells
Background :
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
UniProt :
P35226
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Purified Rabbit Polyclonal Antibody (Pab) |Synonym Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; PCGF4; RNF51 |Host Rabbit |Specificity This BMI1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 281-314 amino acids from the C-terminal region of human BMI1. |Species Reactivity Human, Mouse |Applications IF~~1:25WB~~1:1000-1:2000 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Research areas Cancer;Cell Biology;Stem Cells |Target |Background Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. |Cellular localization Nucleus. Cytoplasm. |UniProt P35226 |References |References Alkema M.J.,et al.Hum. Mol. Genet. 2:1597-1603(1993).Ota T.,et al.Nat. Genet. 36:40-45(2004).Deloukas P.,et al.Nature 429:375-381(2004).Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.Levy L.S.,et al.Oncogene 8:1833-1838(1993). |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-BMI1 Polyclonal Antibody(C-term)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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