Product Name :
PF-06471553
Description:
PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM.
CAS:
1808094-07-6
Molecular Weight:
467.54
Formula:
C23H25N5O4S
Chemical Name:
N-(2-cyclobutyl-2H-1,2,3-triazol-4-yl)-2-[2-(3-methoxyphenyl)acetyl]-2,3-dihydro-1H-isoindole-5-sulfonamide
Smiles :
COC1=CC(CC(=O)N2CC3C=C(C=CC=3C2)S(=O)(=O)NC2C=NN(N=2)C2CCC2)=CC=C1
InChiKey:
GRXCLNMCJWKTAT-UHFFFAOYSA-N
InChi :
InChI=1S/C23H25N5O4S/c1-32-20-7-2-4-16(10-20)11-23(29)27-14-17-8-9-21(12-18(17)15-27)33(30,31)26-22-13-24-28(25-22)19-5-3-6-19/h2,4,7-10,12-13,19H,3,5-6,11,14-15H2,1H3,(H,25,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM.|Product information|CAS Number: 1808094-07-6|Molecular Weight: 467.54|Formula: C23H25N5O4S|Chemical Name: N-(2-cyclobutyl-2H-1,2,3-triazol-4-yl)-2-[2-(3-methoxyphenyl)acetyl]-2,3-dihydro-1H-isoindole-5-sulfonamide|Smiles: COC1=CC(CC(=O)N2CC3C=C(C=CC=3C2)S(=O)(=O)NC2C=NN(N=2)C2CCC2)=CC=C1|InChiKey: GRXCLNMCJWKTAT-UHFFFAOYSA-N|InChi: InChI=1S/C23H25N5O4S/c1-32-20-7-2-4-16(10-20)11-23(29)27-14-17-8-9-21(12-18(17)15-27)33(30,31)26-22-13-24-28(25-22)19-5-3-6-19/h2,4,7-10,12-13,19H,3,5-6,11,14-15H2,1H3,(H,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 150 mg/mL (320.Desipramine web 83 mM).Sevelamer References |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32448942 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PF-06471553 (6f) is a potent and selective monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM, and shows >160 fold in vitro selectivity for MGAT3 over DGAT1 (IC50, >50 μM), DGAT2 (IC50, >100 μM), MGAT1 (IC50, 14.9 μM), and MGAT2 (IC50, 19.8 μM). PF-06471553 exhibits inhibitory activity against MGAT3 in HEK-293 cells with an IC50 of 205 nM (pIC50, 6.69).|In Vivo:|PF-06471553 (200 mg/kg, p.o.) in addition with (DGAT1 and DGAT2) inhibitors shows additional inhibition of glycerol-d5 incorporated triolein in hMGAT3 mice, and with no effect on WT mice.|Products are for research use only. Not for human use.|