Malaria remains a significant public health challenge in tropical regions, particularly in endemic areas such as Jharkhand, India. This study aimed to investigate the influence of Plasmodium falciparum and Plasmodium…
**Background** Dihydrofolate reductase (DHFR) is a critical enzyme in the folate pathway, responsible for reducing dihydrofolate to tetrahydrofolate, which serves as a vital precursor for the synthesis of DNA and…
Hepatocellular carcinoma (HCC) remains a major global health challenge, ranking as the fifth most common cancer and third leading cause of cancer-related mortality. Despite advances in surgical resection, liver transplantation,…
DNA methylation is a fundamental epigenetic mechanism that plays a crucial role in regulating gene expression without altering the underlying DNA sequence. This process involves the addition of a methyl…
**Background** Human epidermal growth factor receptor 2 (HER2) is a member of the epidermal growth factor receptor (EGFR) family and plays a critical role in promoting cell proliferation, survival, and…
Delirium and dementia are two of the most prevalent causes of cognitive impairment among older adults, yet their interplay remains poorly understood. Accumulating evidence indicates that dementia is a leading…
**Background** Inflammatory diseases, such as relapsing-remitting multiple sclerosis (RRMS), Crohn’s disease, and non-infectious uveitis, are often characterized by the abnormal infiltration of immune cells into target organs. A critical step…
Within a large-scale mutagenesis screen using N-ethyl-N-nitrosourea (ENU) in male C3HeB/FeJ mice, a new mutant allele designated Aey80 was identified based on its distinct small-eye phenotype. This mutation resulted in…
**Background** Human cytomegalovirus (HCMV) is a significant opportunistic pathogen that can cause severe systemic disease, particularly in immunocompromised individuals such as hematopoietic stem cell transplant recipients. The management of CMV…
25-Hydroxycholesterol (25OHC), an enzymatically derived oxysterol, plays a critical role in modulating lipid metabolism and immune responses. It is synthesized in macrophages in response to interferons and exhibits broad antiviral…